The Basics
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.Stay up to date on research and information
Sign Up for FORCE NewslettersInformation for People with an Inherited Mutations
Inherited mutations in the gene increase the risk of ovarian cancer. Research on whether an inherited mutation increases the risk for other cancers is ongoing. See our Cancer Risk section for more information.
There are guidelines for screening and prevention for cancer in people with a mutation. Clinical trials may also be available. See our Risk Management section for more information about screening and prevention options.
People with a mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information about treatment clinical trials for people with a mutation.
Inheriting two mutations in —one from each parent—causes a rare disease known as Fanconi anemia. See our Other Considerations section for more information about this disease.
More about
The name stands for " Interacting Protein 1." The gene is located on chromosome 17. works with to repair damage. Although the two genes work together, the effects of a mutation are different; people with a mutation do not have the same cancer risk as people with a mutation.
Get Support
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once registered, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meetings.
Related Resources
The following resources focus on , and mutations:
- Video: Cancer Risks, Screening & Prevention for People w/ , , & Other Genes
- FORCE's eXaming the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.