The Basics
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.Stay up to date on research and information
Sign Up for FORCE NewslettersInformation for People with Inherited MUTYH Mutations
People who inherit mutations in both copies of their MUTYH gene have MUTYH-associated polyposis (MAP). People with MAP are at high risk for several types of cancer.
People with a mutation in only one copy of their MUTYH gene do not develop MAP. These people have a slightly increased risk for colorectal cancer. See our Cancer Risk section for more information.
There are guidelines for screening and prevention for certain cancers in people with MAP and for people with a single MUTYH mutation. See our Risk Management section for more information about screening recommendations.
People with MAP who have been diagnosed with cancer may qualify for specific clinical trials. Visit our Cancer Treatment section for more information about treatment clinical trials and other resources for people diagnosed with cancer.
Because of the high lifetime risk of cancer with MAP, people with MAP of reproductive age may wish to speak with a genetics expert about options related to family planning. See our Other Considerations section for more information.
Related Resources
The following resources focus on FAP, AFAP and MAP:
- FORCE blog: Hereditary Colorectal Cancer: My AFAP Story
- Genetics Home Reference is a site from the U.S. Library of Medicine that provides consumer-friendly information about the effects of inherited mutations in APC and MUTYH on people's health.
- Colorectal Cancer Alliance is a nonprofit organization with a focus on colorectal cancer treatment, detection and prevention.
- FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once you register, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.