The Basics
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.Stay up to date on research and information
Sign Up for FORCE NewslettersGeneral Information for People with Inherited Mutations
People with an in have an increased risk for certain cancers. See the Cancer Risk section for more information. There are guidelines for prevention for certain cancers in people with a mutation. There also may be clinical trials available for people who test positive for a mutation. See our Risk Management section for more information about medical recommendations in people with mutations.
People who have a mutation who have been diagnosed with cancer may qualify for specific treatment or clinical trials. Visit the Cancer Treatment section for more information about clinical trials for people with a mutation.
Inheriting a mutation from both parents can cause Fanconi anemia. See our Other Considerations section for more information about this disorder.
More information about the gene
The gene is located on chromosome 17. is involved in repair.
Get Support
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once registered, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meetings.
Related Resources
The following resources focus on , and mutations:
- Video: Cancer Risks, Screening & Prevention for People w/ , , & Other Genes
- FORCE's eXaming the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.
Open Clinical Trials
NCT02665195: Registry Of MultiPlex Testing (PROMPT). PROMPT is an online research registry. The goal of PROMPT is to help researchers to better understand the risks that are linked to mutations in less well-studied genes. People with inherited mutations can enroll in PROMPT to help researchers learn more about cancer risks.