The Basics
Read about different genes that are linked to hereditary cancer, their associated risks and guidelines for screening, preventing and treating cancers in people with inherited mutations in these genes.Stay up to date on research and information
Sign Up for FORCE NewslettersInformation for People with Inherited Mutations
Inherited mutations in are associated with . People with an in have increased risk for certain cancers. The lifetime cancer risk for people with is high, and many people have more than one cancer. See our Cancer Risk section for more information.
There are guidelines for screening and prevention for certain cancers in people with a mutation. See our Risk Management section for more information about screening and prevention options in people with this mutation.
People with an inherited mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information.
Certain families with mutations may have Li-Fraumeni-like syndrome. See our Other Considerations section for more information about this disease.
More information about the gene
The (tumor suppressor protein 53 or p53) gene is located on chromosome 17. helps in the repair of damaged .
Get Support
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once registered, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meetings.
Related Resources
The following resources focus on mutations.
- FORCE resources:
- Information: gene mutations overview
- Information: cancer risk
- Information: risk management
- Genetics Home Reference: information about the effects of an inherited mutation
- The National Organization for Rare Disorders (NORD): section on Li-Fraumeni syndrome
- Association