Breast Cancer Risk Management

Every person is at risk for breast cancer and the risk increases with age. A woman in the general population has about a 13 percent lifetime risk of developing breast cancer. This means that one out of every eight women will get breast cancer in their lifetime. In average risk women, the risk is highest after age 60. A man in the general population has a very low risk for breast cancer, less than 1 percent. People with an inherited mutation in any of the genes listed below, have a higher-than-average risk for breast cancer. 

Breast cancer screening and risk reduction

There are different options for managing breast cancer risk, including:

• breast screening
• medications to reduce risk
• surgery to reduce risk

Which option you choose for managing your breast cancer risk will depend on several factors, including:

• your age
• your gender
• the presence of an inherited gene mutation
• your personal and family history of cancer
• other risk factors
• personal preferences

There are different national expert guidelines for breast cancer risk management, which are based on your level of risk. Speak with your healthcare provider to decide on a risk management plan and schedule that is right for you. 

Genes linked to breast cancer risk 

Inherited mutations in the following genes have been linked to increased risk for breast cancer in women:

ATM	PALB2
BARD1	PTEN
BRCA1	RAD51C
BRCA2	RAD51D
CDH1	STK11
CHEK2	TP53
NF1 (only in people with neurofibromatosis)

 

The following genes have been linked to an increased risk for male breast cancer:

• BRCA1 
• BRCA2
• CHEK2
• PALB2

Other factors linked to breast cancer risk

Factors such as diet, weight, exercise, smoking, alcohol consumption hormone exposure, and environmental exposures can affect breast cancer risk in the general population and in people at high risk for cancer. More research is needed to understand how much these factors influence risk in people with inherited mutations.